Fresh analysis suggests that people who come off blockbuster slimming jabs like Wegovy and Mounjaro can put back on reduced body mass far faster than those who halt traditional diet and exercise plans.
Findings released in a prominent health publication shows that while obese people frequently drop a large proportion of their body weight while using the jabs, the weight returns at an average rate of 0.8 kg per month once they quit.
"People buying these medications need to be informed of the risk of rapid rebound weight gain when the therapy concludes," cautioned expert Dr. Susan Jebb.
This pace of regain means a reversion to starting mass within about one and a half years.
Weighing Treatments
The study, which looked at dozens of trials involving thousands of participants, compared the results of these new drugs with other pills.
The team note that people who shed pounds through dieting typically have a more gradual weight regain—approximately 100 grams monthly—after stopping.
Understanding the Quick Regain
Experts propose the mode of action of the jabs is key to understanding the heightened rebound.
These medications copy a natural hormone called glucagon-like peptide-1, which moderates hunger.
"Long-term administration of the hormone concentrations far above than normal might result in the system to generate a reduced amount of its own natural GLP-1, and could lessen responsiveness to its effects," said Dr. Adam Collins, a nutrition expert.
"Discontinuation of this medication leads to hunger is unsuppressed, making overeating a significant risk."
An Ongoing Issue?
The NHS advise the injections for individuals with obesity-related medical conditions, accompanied by prescribed diet and exercise modifications.
Professionals argue that, given the significant potential of relapse, the treatment should be considered long-term.
This perspective is supported by pharmaceutical companies, who say that the results "emphasize the persistent nature of obesity," similar to managing conditions like hypertension.
User Experiences
People who have stopped the jabs describe a intense return of cravings.
"I experienced something activating and I was suddenly starving," recalled an individual.
The struggle is exacerbated if users have not established lasting lifestyle or habit changes during therapy.
Significant Adoption
Figures show that millions of people in the UK have tried these injections in the last 12 months, with interest remaining high.
- Adoption is more common among women compared to males.
- The 40s and 50s age group shows the highest level of interest.
- Many access the drugs through private prescriptions rather than public health services.
Finally, experts emphasize that while the jabs are effective tools for weight loss, they are not a standalone cure and long-term success likely depends on combined lifestyle support.
